Mehreen graduated from UCLA in 1993 with a Film, Television and Video certificate, and returned to Pakistan to direct and produce made-for-TV movies and drama series/serials under the banner of TasVeer Productions, almost all of which were critically acclaimed by the Pakistani press.

She went on to direct tele-films and TV series for numerous TV channels in Pakistan, in addition to a number of short films which have aired in festivals worldwide. Her award-winning films include 'Daughters of the Late Colonel', and a four-part television show: ' Sanam Gazida, Afsoon Khawab, Deeda-e-Purkhoon, and Lal Baig.' 'Ramchand Pakistani' is her first feature length film, to be released later this year.

Mehreen has been a member of the National Board of Film Censors in Karachi, a founding member of WAR (War Against Rape), the KaraFilm Festival in Karachi, and has also served as a juror at the Leeds International Film Festival in 2002. She currently resides in New York City .